Near-infrared measurements of hemodynamic and oxygenation changes on the frontal cortex during breath holding, hyperventilation, and natural sleep

Tommi EJ. Noponen; Kalle Kotilahti; Jussi Toppila; Ilkka T. Nissila; Tapani Salmi; Timo T. Kajava; Toivo E. Katila

doi:10.1117/12.476809

29 July 2003 Near-infrared measurements of hemodynamic and oxygenation changes on the frontal cortex during breath holding, hyperventilation, and natural sleep

Tommi EJ. Noponen, Kalle Kotilahti, Jussi Toppila, Ilkka T. Nissila, Tapani Salmi, Timo T. Kajava, Toivo E. Katila

Author Affiliations +

Proceedings Volume 4955, Optical Tomography and Spectroscopy of Tissue V; (2003) https://doi.org/10.1117/12.476809
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

We have developed a frequency-domain near-infrared device suitable for physiological studies in human. In this work, a four-channel configuration of the instrument is applied to monitor hemodynamic and oxygenation changes in the frontal cortex of volunteers during different ventilation tasks. We use four different source-receiver separations (2, 3, 4, and 5 cm) and three wavelengths (760, 808, and 830 nm) to test the sensitivity of these parameters to cardiovascular and metabolic changes. Low-frequency oscillations (~ 0.02 Hz) and variations in heart rate during different ventilation tasks are investigated as well. We also study physiological changes during natural sleep using the frequency-domain instrument simultaneously with a polysomnography system containing a pulse oximeter. Our results indicate that hemodynamic and oxygenation changes in the frontal cortex during natural sleep can be detected using near-infrared measurements.

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Tommi EJ. Noponen, Kalle Kotilahti, Jussi Toppila, Ilkka T. Nissila, Tapani Salmi, Timo T. Kajava, and Toivo E. Katila "Near-infrared measurements of hemodynamic and oxygenation changes on the frontal cortex during breath holding, hyperventilation, and natural sleep", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); https://doi.org/10.1117/12.476809

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