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22 July 2003 Development of SH-SAW sensors for measurement of the properties of protein solutions
Yongrae Roh, Yongjun Kwon, Kyungho Kim, Kwangnak Koh, Jaeho Kim
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Proceedings Volume 5055, Smart Structures and Materials 2003: Smart Electronics, MEMS, BioMEMS, and Nanotechnology; (2003) https://doi.org/10.1117/12.483576
Event: Smart Structures and Materials, 2003, San Diego, California, United States
Abstract
We developed new surface acoustic wave (SAW) sensors to measure the properties of protein solutions applying a particular organic thin film on the delay line of transverse type SAW devices. Each delay line is configured as an oscillator. The delay line for a sensing channel is coated with a gold film on which an antibody layer is immobilized by protein A. The sensing delay line selectively adsorbs antigens when exposed to a protein solution, which results in phase delay changes due to the mass loading effects induced by the adsorbed antigens. The other delay line is uncoated for use as a stable reference. The relative change in the frequency of the two oscillators is monitored to measure the concentration of the antigens. Sensor properties investigated include selectivity, sensitivity, response time and stability in response to the antigen concentration as well as the viscosity and electrical conductivity of the protein solution.
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Yongrae Roh, Yongjun Kwon, Kyungho Kim, Kwangnak Koh, and Jaeho Kim "Development of SH-SAW sensors for measurement of the properties of protein solutions", Proc. SPIE 5055, Smart Structures and Materials 2003: Smart Electronics, MEMS, BioMEMS, and Nanotechnology, (22 July 2003); https://doi.org/10.1117/12.483576
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KEYWORDS
Sensors
Proteins
Oscillators
Crystals
Liquids
Environmental sensing
Acoustics
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