Investigation of myocardial photodynamic revascularization method on ischemic rat myocardium model

S. Yu. Vasilchenko; A. A. Stratonnikov; A. I. Volkova; V. B. Loschenov; E. A. Sheptak; S. S. Kharnas

doi:10.1117/12.697420

24 July 2006 Investigation of myocardial photodynamic revascularization method on ischemic rat myocardium model

S. Yu. Vasilchenko, A. A. Stratonnikov, A. I. Volkova, V. B. Loschenov, E. A. Sheptak, S. S. Kharnas

Author Affiliations +

Proceedings Volume 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII; 61631N (2006) https://doi.org/10.1117/12.697420
Event: Saratov Fall Meeting 2005, 2005, Saratov, Russian Federation

Abstract

Ischemic heart disease is one of the leading reasons of invalidisation and death rate of able-bodied citizens in the world. There are many various surgical and medicamentous methods of its treatment for today, however all these methods have restrictions in application. Our work was directed at initiation possibility clarification of ischemic myocardium revascularization by means of making necrosis with photodynamic therapy. The investigation was carried out in rats with the ischemia artificial made by means of left coronary artery ligation. Level of Photosense photosensitizer accumulation in ischemic and normal rat myocardium zones was defined. Myocardial photodynamic revascularization procedure of ischemic rat myocardium was carried out. Morphological analysis of the myocardium preparations showed the presence of active revascularization of ischemic myocardium after photodynamic therapy. The method of ischemia level estimation based on spectral optical definition of blood oxygen saturation was developed.

Citation Download Citation

S. Yu. Vasilchenko, A. A. Stratonnikov, A. I. Volkova, V. B. Loschenov, E. A. Sheptak, and S. S. Kharnas "Investigation of myocardial photodynamic revascularization method on ischemic rat myocardium model", Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 61631N (24 July 2006); https://doi.org/10.1117/12.697420

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Heart

Ischemia

Blood oxygen saturation

Luminescence

Photodynamic therapy

Absorption

Picosecond phenomena

Show All Keywords

Keywords/Phrases

Search In:

Publication Years