Study of molecular mechanisms of UV-induced aggregation of crystallins and possibility of maintaining eye lens transparency

L. V. Soustov; E. V. Chelnokov; N. M. Bityurin; A. L. Kiselev; V. V. Nemov; Yu. V. Sergeev; M. A. Ostrovsky

doi:10.1117/12.678391

19 May 2006 Study of molecular mechanisms of UV-induced aggregation of crystallins and possibility of maintaining eye lens transparency

L. V. Soustov, E. V. Chelnokov, N. M. Bityurin, A. L. Kiselev, V. V. Nemov, Yu. V. Sergeev, M. A. Ostrovsky

Author Affiliations +

Proceedings Volume 6257, ICONO 2005: Nonlinear Laser Spectroscopy, High Precision Measurements, and Laser Biomedicine and Chemistry; 62570X (2006) https://doi.org/10.1117/12.678391
Event: ICONO 2005, 2005, St. Petersburg, Russian Federation

Abstract

The effect of D-pantethine and L-carnosine on the rate of UV-induced (XeC1 laser λ = 308 nm) aggregation of a mixture of βL-crystallin and α-crystallin is studied. We also demonstrate that the suggested by us combination of short-chain peptides shows better protective properties with respect to UV-induced aggregation than known anti-cataract agents.

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L. V. Soustov, E. V. Chelnokov, N. M. Bityurin, A. L. Kiselev, V. V. Nemov, Yu. V. Sergeev, and M. A. Ostrovsky "Study of molecular mechanisms of UV-induced aggregation of crystallins and possibility of maintaining eye lens transparency", Proc. SPIE 6257, ICONO 2005: Nonlinear Laser Spectroscopy, High Precision Measurements, and Laser Biomedicine and Chemistry, 62570X (19 May 2006); https://doi.org/10.1117/12.678391

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