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This work described the development of high throughput human DNA purification process
with the amino-functionalized silica coated magnetic nanoparticles. The magnetic nanoparticles were
synthesized with average particle size of 9 nm and silica-coated magnetic nanoparticles were
obtained by controlling the coating thicknesses on magnetic nanoparticles. The silica coating
thickness could be uniform-sized in the diameter of 10-40 nm by a sol-gel approach. The surface
modification was performed with amino-functionalized organic silanes on silica coated magnetic
nanoparticles. The spectroscopic measurements such as a FT-IR(ATR-method) and Vibrational
Sample Magnetometer (VSM) were used to characterize the chemical structures and magnetic
strengths. To elucidate the relationship among the surface area, pore size distribution and reactivity of
the materials, XRD, TEM, BET and Zeta potential were used. The use of functionalized
self-assembled magnetic nanoparticles for human DNA separation process give a lot of advantages
rather than the conventional silica based process.
Jeong Ho Chang andKyung Ja Kim
"Self-assembled magnosilicate nanocapturer for the in-situ separation of human DNA and proteins", Proc. SPIE 6416, Biomedical Applications of Micro- and Nanoengineering III, 641610 (14 December 2006); https://doi.org/10.1117/12.695983
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Jeong Ho Chang, Kyung Ja Kim, "Self-assembled magnosilicate nanocapturer for the in-situ separation of human DNA and proteins," Proc. SPIE 6416, Biomedical Applications of Micro- and Nanoengineering III, 641610 (14 December 2006); https://doi.org/10.1117/12.695983