Paper
13 February 2007 Deep reflection-mode photoacoustic imaging and resolution scalability with depth
Author Affiliations +
Abstract
A deep reflection-mode photoacoustic (PA) imaging system was designed and implemented to visualize deep structures in biological tissues. To achieve good penetration depth, we chose near IR laser pulses at 804 nm wavelength for the generation of photoacoustic waves. To avoid overshadowing the deep PA signals by the surface PA signals, we employed dark-field illumination. To achieve good lateral resolution, we chose spherically focused high-numericalaperture ultrasonic transducers with 5 MHz or 10 MHz center frequencies. By using these transducers, we achieved 153 &mgr;m and 130 &mgr;m axial resolutions, respectively, at 19.5 mm depth in 10% porcine gelatin containing 1% intralipid. The system was applied to imaging internal organs of small animals. Compared with our previous high-frequency (50-MHz) photoacoustic microscope, we scaled up the imaging depth while maintaining the ratio of the imaging depth to axial resolution more than 100. In addition, we studied the scalability of the imaging depth and the resolution with ultrasound frequency.
© (2007) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kwang Hyun Song and Lihong V. Wang "Deep reflection-mode photoacoustic imaging and resolution scalability with depth", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643722 (13 February 2007); https://doi.org/10.1117/12.698823
Lens.org Logo
CITATIONS
Cited by 1 scholarly publication.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Photoacoustic spectroscopy

Transducers

Brain

Blood vessels

Image resolution

Kidney

Neuroimaging

Back to Top