Laser microinterferometer for estimation of red blood cell volume

Grigory Lazarev; Alexander Sedashev

doi:10.1117/12.740975

2 May 2007 Laser microinterferometer for estimation of red blood cell volume

Grigory Lazarev, Alexander Sedashev

Proceedings Volume 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII; 653516 (2007) https://doi.org/10.1117/12.740975
Event: Saratov Fall Meeting 2006, 2006, Saratov, Russian Federation

Abstract

Phase contrast and interference microscopes are widely used for microbiological and biomedical research. However most of them can't give high precision quantitative estimation of cell volume and morphology due to modest resolution. We propose scheme based on a modified laser Linnik microinterferometer providing high both phase and spatial resolutions. Red blood cell volume is calculated using integration of phase height distribution; limits of integration are determined by Canny edge detection procedure. Experimental volume estimation fits well to volume data obtained with other methods.

Citation Download Citation

Grigory Lazarev and Alexander Sedashev "Laser microinterferometer for estimation of red blood cell volume", Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 653516 (2 May 2007); https://doi.org/10.1117/12.740975

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