Microfluidic chamber with acoustic actuation by LiNbO3 interdigital transducers for tumor cell investigations

Matthias Gruber; Richard Heming; Eva-Maria Schnaeker; Thomas Seiler

doi:10.1117/12.726338

15 May 2007 Microfluidic chamber with acoustic actuation by LiNbO₃ interdigital transducers for tumor cell investigations

Matthias Gruber, Richard Heming, Eva-Maria Schnaeker, Thomas Seiler

Author Affiliations +

Proceedings Volume 6589, Smart Sensors, Actuators, and MEMS III; 65890E (2007) https://doi.org/10.1117/12.726338
Event: Microtechnologies for the New Millennium, 2007, Maspalomas, Gran Canaria, Spain

Abstract

A microfluidic system is presented that enables in-vitro investigations on tumor cells under conditions similar to those in a blood vessel. Microscopic test objects are immersed in a liquid that circulates in a closed-loop PDMS microchannel and that is sandwiched between a glass and a LiNbO₃ wafer which are both transparent to enable visual access. The actuation is achieved electroacoustically by interdigital transducers on the LiNbO₃ wafer generating a Rayleigh-type surface acoustic wave that transfers momentum to the liquid. The envisaged medical application for this chamber is briefly sketched, its design and fabrication are discussed, and the operability is demonstrated.

Citation Download Citation

Matthias Gruber, Richard Heming, Eva-Maria Schnaeker, and Thomas Seiler "Microfluidic chamber with acoustic actuation by LiNbO₃ interdigital transducers for tumor cell investigations", Proc. SPIE 6589, Smart Sensors, Actuators, and MEMS III, 65890E (15 May 2007); https://doi.org/10.1117/12.726338

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