Validation of a dual reporter system for in vivo heat-mediated HSP70 expression in prostate tumors

Anil Shetty; Amer Najjar; Andrew M. Elliott; Adam Springer; R. Jason Stafford; Ken Diller; Juri Gelovani; John D. Hazle

doi:10.1117/12.763361

8 February 2008 Validation of a dual reporter system for in vivo heat-mediated HSP70 expression in prostate tumors

Anil Shetty, Amer Najjar, Andrew M. Elliott, Adam Springer, R. Jason Stafford, Ken Diller, Juri Gelovani, John D. Hazle

Author Affiliations +

Proceedings Volume 6842, Photonic Therapeutics and Diagnostics IV; 68420T (2008) https://doi.org/10.1117/12.763361
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Minimally invasive thermal therapy is gaining ground as a new treatment modality of prostate tumors. However, further understanding of molecular events like HSP70 expression is required for treatment planning and coordination with chemotherapy and radiation. Metastatic prostate tumor (PC3 MM2) cells, transduced with reporter genes, were utilized to study the expression of HSP70 induced by normal and nanoshell-mediated heating. A correlation was noted between HSP70 expression, cellular viability and heating temperatures. This imaging paradigm can be developed into a PET-MR thermal treatment regimen, which would include dosimetry planning, real time temperature monitoring and post treatment assessment of tumor response at a cellular level.

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Anil Shetty, Amer Najjar, Andrew M. Elliott, Adam Springer, R. Jason Stafford, Ken Diller, Juri Gelovani, and John D. Hazle "Validation of a dual reporter system for in vivo heat-mediated HSP70 expression in prostate tumors", Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 68420T (8 February 2008); https://doi.org/10.1117/12.763361

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