Optoacoustic 3D whole-body tomography: experiments in nude mice

Hans-Peter Brecht; Richard Su; Matt Fronheiser; Sergey A. Ermilov; André Conjusteau; Anton Liopo; Massoud Motamedi; Alexander A. Oraevsky

doi:10.1117/12.812319

24 February 2009 Optoacoustic 3D whole-body tomography: experiments in nude mice

Hans-Peter Brecht, Richard Su, Matt Fronheiser, Sergey A. Ermilov, André Conjusteau, Anton Liopo, Massoud Motamedi, Alexander A. Oraevsky

Author Affiliations +

Proceedings Volume 7177, Photons Plus Ultrasound: Imaging and Sensing 2009; 71770E (2009) https://doi.org/10.1117/12.812319
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

We developed a 3D whole-body optoacoustic tomography system for applications in preclinical research on mice. The system is capable of generating images with resolution better than 0.6 mm. Two pulsed lasers, an Alexandrite laser operating at 755 nm and a Nd:YAG laser operating at 532 nm and 1064nm were used for light delivery. The tomographic images were obtained while the objects of study (phantoms or mice) were rotated within a sphere outlined by a concave arc-shaped array of 64 piezo-composite transducers. During the scan, the mouse was illuminated orthogonally to the array with two wide beams of light from a bifurcated fiber bundle. Illumination at 532 nm showed superficial vasculature, but limited penetration depth at this wavelength prevented the detection of deeper structures. Illumination at 755 and 1064 nm showed organs and blood vessels, respectively. Filtering of the optoacoustic signals using high frequency enhancing wavelets further emphasized the smaller blood vessels.

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Hans-Peter Brecht, Richard Su, Matt Fronheiser, Sergey A. Ermilov, André Conjusteau, Anton Liopo, Massoud Motamedi, and Alexander A. Oraevsky "Optoacoustic 3D whole-body tomography: experiments in nude mice", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71770E (24 February 2009); https://doi.org/10.1117/12.812319

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