Bio-mimetic hollow scaffolds for long bone replacement

Bert Müller; Hans Deyhle; Fabienne C. Fierz; Stephan H. Irsen; Jin Yu Yoon; Shpend Mushkolaj; Oliver Boss; Elke Vorndran; Uwe Gburek; Özer Degistirici; Michael Thie; Barbara Leukers; Felix Beckmann; Frank Witte

doi:10.1117/12.825487

21 August 2009 Bio-mimetic hollow scaffolds for long bone replacement

Bert Müller, Hans Deyhle, Fabienne C. Fierz, Stephan H. Irsen, Jin Yu Yoon, Shpend Mushkolaj, Oliver Boss, Elke Vorndran, Uwe Gburek, Özer Degistirici, Michael Thie, Barbara Leukers, Felix Beckmann, Frank Witte

Author Affiliations +

Proceedings Volume 7401, Biomimetics and Bioinspiration; 74010D (2009) https://doi.org/10.1117/12.825487
Event: SPIE NanoScience + Engineering, 2009, San Diego, California, United States

Abstract

The tissue engineering focuses on synthesis or regeneration of tissues and organs. The hierarchical structure of nearly all porous scaffolds on the macro, micro- and nanometer scales resembles that of engineering foams dedicated for technical applications, but differ from the complex architecture of long bone. A major obstacle of scaffold architecture in tissue regeneration is the limited cell infiltration as the result of the engineering approaches. The biological cells seeded on the three-dimensional constructs are finally only located on the scaffold's periphery. This paper reports on the successful realization of calcium phosphate scaffolds with an anatomical architecture similar to long bones. Two base materials, namely nano-porous spray-dried hydroxyapatite hollow spheres and tri-calcium phosphate powder, were used to manufacture cylindrically shaped, 3D-printed scaffolds with micro-passages and one central macro-canal following the general architecture of long bones. The macro-canal is built for the surgical placement of nerves or larger blood vessels. The micro-passages allow for cell migration and capillary formation through the entire scaffold. Finally, the nanoporosity is essential for the molecule transport crucial for signaling, any cell nutrition and waste removal.

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Bert Müller, Hans Deyhle, Fabienne C. Fierz, Stephan H. Irsen, Jin Yu Yoon, Shpend Mushkolaj, Oliver Boss, Elke Vorndran, Uwe Gburek, Özer Degistirici, Michael Thie, Barbara Leukers, Felix Beckmann, and Frank Witte "Bio-mimetic hollow scaffolds for long bone replacement", Proc. SPIE 7401, Biomimetics and Bioinspiration, 74010D (21 August 2009); https://doi.org/10.1117/12.825487

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