Detection of precancerous cervical conditions using elastic light single-scattering spectroscopy

Murat Canpolat; Tuba Denkceken; Seyda Karaveli; Elif Pestereli; Gülgün Erdoğan; Deniz Özel; Uğur Bilge; Tayup Simsek

doi:10.1117/12.845830

26 February 2010 Detection of precancerous cervical conditions using elastic light single-scattering spectroscopy

Murat Canpolat, Tuba Denkceken, Seyda Karaveli, Elif Pestereli, Gülgün Erdoğan, Deniz Özel, Uğur Bilge, Tayup Simsek

Proceedings Volume 7573, Biomedical Applications of Light Scattering IV; 75730V (2010) https://doi.org/10.1117/12.845830
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We have investigated the potential application of elastic light single-scattering spectroscopy (ELSSS) as an adjunctive tool for screening of cervical precancerous lesions non-invasively and in real time. Ex-vivo measurements were performed on 95 cervix biopsy tissue of 60 patients. Normal cervix tissue from 10 patients after hysterectomy was used as a control group. Correlation between ELSSS spectra and histopathology results were investigated. It was found that the spectral slope was positive for all the spectra taken on normal cervix tissue samples from the control group. We assumed that if there is only one spectrum with a negative spectral slope among the all spectra taken on a biopsy specimen, the biopsy specimen is pathologically abnormal. This shows that pap smear and ELSSS results are in good agreement. Most biopsy tissue samples had both positive and negative spectral slopes. Therefore, we calculated the percentage of negative spectral slopes and hypothesized that this was correlated to dysplastic percentage of the epithelial tissue of the biopsy material. The ROC curve was calculated using the dysplastic percentage and high squamous intraepithelial lesion (HSIL) and low squamous intraepitherlial lesions (LSIL) biopsy specimens were differentiated from non HSIL and LSIL with a sensitivity and specificity of 70.4% and 66.7% respectively, with p < 0.05.

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Murat Canpolat, Tuba Denkceken, Seyda Karaveli, Elif Pestereli, Gülgün Erdoğan, Deniz Özel, Uğur Bilge, and Tayup Simsek "Detection of precancerous cervical conditions using elastic light single-scattering spectroscopy", Proc. SPIE 7573, Biomedical Applications of Light Scattering IV, 75730V (26 February 2010); https://doi.org/10.1117/12.845830

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