Near-infrared optical mammography with broadband spectral imaging for spatially resolved oximetry

Yang Yu; Angelo Sassaroli; Marc J. Homer; Roger A. Graham; Sergio Fantini

doi:10.1117/12.873945

17 February 2011 Near-infrared optical mammography with broadband spectral imaging for spatially resolved oximetry

Yang Yu, Angelo Sassaroli, Marc J. Homer, Roger A. Graham, Sergio Fantini

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 78962G (2011) https://doi.org/10.1117/12.873945
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We report the development of an instrument for diffuse spectral imaging of the human breast operating over the wavelength range 650-900 nm. This instrument images the slightly compressed human breast in a planar geometry by performing a tandem scan, over the x-y plane, of a 3 mm illumination optical fiber and a 5 mm collection optical fiber that are collinear and located on opposite sides of the breast. An edge-correction algorithm accounts for breast thickness variability over the x-y plane, a second-derivative imaging algorithm enhances the display of optical inhomogeneities, and a paired-wavelength spectral method yields oxygenation maps. We report our results of oxygenation mapping in eighteen human subjects, two of which are breast cancer patients, one with a ductal carcinoma in situ, the other with an invasive ductal carcinoma.

Citation Download Citation

Yang Yu, Angelo Sassaroli, Marc J. Homer, Roger A. Graham, and Sergio Fantini "Near-infrared optical mammography with broadband spectral imaging for spatially resolved oximetry", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962G (17 February 2011); https://doi.org/10.1117/12.873945

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KEYWORDS

Breast

Mammography

Absorption

Imaging spectroscopy

Tissue optics

Breast cancer

Near infrared spectroscopy

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