Toward in-vivo photoacoustic imaging of human ovarian tissue for cancer detection

Andres Aguirre; Patrick Kumavor; Yasaman Ardeshirpour; Mary M. Sanders; Molly Brewer; Quing Zhu

doi:10.1117/12.875950

17 February 2011 Toward in-vivo photoacoustic imaging of human ovarian tissue for cancer detection

Andres Aguirre, Patrick Kumavor, Yasaman Ardeshirpour, Mary M. Sanders, Molly Brewer, Quing Zhu

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 789908 (2011) https://doi.org/10.1117/12.875950
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Currently, most of the cancers in the ovary are detected when they have already metastasized to other parts of the body. As a result, ovarian cancer has the highest mortality of all gynecological cancers with a 5-year survival rate of 30% or less [1]. The reason is the lack of reliable symptoms as well as the lack of efficacious screening techniques [2,3]. Thus, there is an urgent need to improve the current diagnostic techniques. We have investigated the potential role of co-registered photoacoustic and ultrasound imaging in ovarian cancer detection. In an effort to bring this technique closer to clinical application, we have developed a co-registered ultrasound and photoacoustic transvaginal probe. A fiber coupling assembly has been developed to deliver the light from around the transducer for reflection geometry imaging. Co-registered ultrasound and photoacoustic images of swine ovaries through vagina wall muscle and human ovaries using the aforementioned probe, demonstrate the potential of photoacoustic imaging to non-invasively detect ovarian cancer in vivo.

Citation Download Citation

Andres Aguirre, Patrick Kumavor, Yasaman Ardeshirpour, Mary M. Sanders, Molly Brewer, and Quing Zhu "Toward in-vivo photoacoustic imaging of human ovarian tissue for cancer detection", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789908 (17 February 2011); https://doi.org/10.1117/12.875950

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KEYWORDS

Ovary

Ultrasonography

Ovarian cancer

Photoacoustic spectroscopy

Transducers

Photoacoustic imaging

In vivo imaging

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