Susceptibility of representative dental pathogens to inactivation by the PDT with water-soluble photosensitizers

Ivan Angelov; Vanya Mantareva; Veselin Kussovski; Diter Worle; Hristo Kisov; Marieta Belcheva; Tzvetelina Georgieva; Slavcho Dimitrov

doi:10.1117/12.881011

7 February 2011 Susceptibility of representative dental pathogens to inactivation by the PDT with water-soluble photosensitizers

Ivan Angelov, Vanya Mantareva, Veselin Kussovski, Diter Worle, Hristo Kisov, Marieta Belcheva, Tzvetelina Georgieva, Slavcho Dimitrov

Author Affiliations +

Proceedings Volume 7994, LAT 2010: International Conference on Lasers, Applications, and Technologies; 79941A (2011) https://doi.org/10.1117/12.881011
Event: International Conference on Coherent and Nonlinear Optics (ICONO 2010) and International Conference on Lasers, Applications and Technologies (LAT 2010), 2010, Kazan, Russian Federation

Abstract

In the recent decade the applications of photodynamic therapy (PDT) rapidly increase in several topics and one of areas where the PDT in the future will be play significant role is dentistry. The different photosensitizing complexes with a good water solubility and with absorption with an intensive maximum in the red region (630-690 nm), which makes them suitable for photodynamic treatments, were investigated. The photochemical properties of complexes for singlet oxygen generation were investigated and were shown relations between uptake levels and light intensity to achieve increase in photodynamic efficacy. Photodynamic efficacy against fungi Candida albicans and bacteria's E. faecalis, MRSA and S. Mutans in planktonic media was evaluated. The high photodynamic efficacy was shown for SiPc at very low concentrations (0.9 μM) and light doses of 50 J cm^-2 by intensity of light 60 mW cm^-2. The photodynamic response for E. faecalis, MRSA and S. Mutans, after treatments with different photosensitizers show strong dependence on concentrations of photsensitzers and micro organisms. The level of inactivation of the pathogen bacteria's from 1-2 degree of initial concentration up to full inactivation was observed. The studied complexes were compared to the recently studied Methylene blue, Haematoporphyrine and tetra-methylpirydiloxy Zn(II)- phthalocyanines and experimental results show that some of them have a good potential for inactivation of representative pathogenic bacterial strains. Experimental results also indicate that photodynamic therapy appears an effective method for inactivation of oral pathogenic bacterias and fungi.

Citation Download Citation

Ivan Angelov, Vanya Mantareva, Veselin Kussovski, Diter Worle, Hristo Kisov, Marieta Belcheva, Tzvetelina Georgieva, and Slavcho Dimitrov "Susceptibility of representative dental pathogens to inactivation by the PDT with water-soluble photosensitizers", Proc. SPIE 7994, LAT 2010: International Conference on Lasers, Applications, and Technologies, 79941A (7 February 2011); https://doi.org/10.1117/12.881011

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available