Integrated optical sensor array for biochemical multiparameter analysis

Daniel Pergande; Peter Lützow; Sophie Huscher; Dominik Gausa; Helmut Heidrich

doi:10.1117/12.906375

31 January 2012 Integrated optical sensor array for biochemical multiparameter analysis

Daniel Pergande, Peter Lützow, Sophie Huscher, Dominik Gausa, Helmut Heidrich

Proceedings Volume 8212, Frontiers in Biological Detection: From Nanosensors to Systems IV; 82120L (2012) https://doi.org/10.1117/12.906375
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

In this paper we demonstrate the ability to analyze a multiple of miniaturized bus-integrated sensor elements at high sensitivity from the superimposed complex overall spectrum by individual frequency modulation of optical microring resonators (MRR) fed by a single bus waveguide. The diverse sensor elements can be coated with biochemically selective adlayers (e.g., antibody molecules) to specifically promote the accumulation of target molecules on the MRR surface. Adhesion of target molecules results in an increase of the MRR resonance frequencies which can be measured at high sensitivity with a picometer accuracy. Readout of each MRR from the complex overall spectrum is performed by using phase sensitive lock-in detection to filter out the individual and selective response to external stimuli. We fabricated test arrays with 12 MRR elements based on silicon nitride material, each element integrated with a heater electrode for thermo-optical modulation of the MRR. A clear readout of the individual MRR by using a tuneable laser source is accomplished in a simple and reliable manner via lock-in detection despite strong overlap of the individual resonances. With our first results, we point out the large potential for multiplexed label-free detection of diverse biomolecular compounds.

Citation Download Citation

Daniel Pergande, Peter Lützow, Sophie Huscher, Dominik Gausa, and Helmut Heidrich "Integrated optical sensor array for biochemical multiparameter analysis", Proc. SPIE 8212, Frontiers in Biological Detection: From Nanosensors to Systems IV, 82120L (31 January 2012); https://doi.org/10.1117/12.906375

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available