Artesunate induces AIF-dependent apoptosis in A549 cells

Chen-juan Zhou; Tong-Sheng Chen

doi:10.1117/12.905017

14 February 2012 Artesunate induces AIF-dependent apoptosis in A549 cells

Chen-juan Zhou, Tong-Sheng Chen

Author Affiliations +

Proceedings Volume 8224, Biophotonics and Immune Responses VII; 82240M (2012) https://doi.org/10.1117/12.905017
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Artesunate (ART), a semi-synthetic derivative of the sesquiterpene artemisinin extracted from the Chinese herb Artemisia annua, exerts a broad spectrum of clinical activity against human cancers. It has been shown that ART induces cancer cells death through apoptosis pathway. This study investigated whether ART treatment induced reactive oxygen species (ROS)-dependent cell death in the apoptosis fashion in human lung adenocarconoma A549 cell line and the proapoptotic protein apoptosis inducing factor (AIF) is involved in ART-induced apoptosis. Cells treated with ART exhibited typical apoptotic morphology as chromatin condensation, margination and shrunken nucleus. ART treatment also induced a loss of mitochondrial membrane potential and AIF release from mitochondria. Silencing AIF can remarkable attenuated ART-induced apoptosis. Collectively, ART induces apoptosis by caspase-independent intrinsic pathway in A549 cells.

Citation Download Citation

Chen-juan Zhou and Tong-Sheng Chen "Artesunate induces AIF-dependent apoptosis in A549 cells", Proc. SPIE 8224, Biophotonics and Immune Responses VII, 82240M (14 February 2012); https://doi.org/10.1117/12.905017

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