Development of a method to image blood flow beneath the skull or tissue using ultrasonic speckle reflections

Jeff Sadler; Zaki Ahmed; Kiyanoosh Shapoori; Adrian Wydra; Eugene Malyarenko; Elena Maeva; Roman Gr. Maev

doi:10.1117/12.2002104

29 March 2013 Development of a method to image blood flow beneath the skull or tissue using ultrasonic speckle reflections

Jeff Sadler, Zaki Ahmed, Kiyanoosh Shapoori , Adrian Wydra, Eugene Malyarenko , Elena Maeva, Roman Gr. Maev

Author Affiliations +

Proceedings Volume 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging; 86720G (2013) https://doi.org/10.1117/12.2002104
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

The interest of our study is the in-vivo transcranial visualization of blood flow without removal of the skull. The strong attenuation, scattering, and distortion by the skull bones (or other tissues) make it difficult to use currently existing methods. However, blood flow can still be detected by using the ultrasonic speckle reflections from the blood cells and platelets (or contrast agents) moving with the blood. The methodology specifically targets these random temporal changes, imaging the owing region and eliminating static components. This process analyzed over multiple exposures allows an image of the blood flow to be obtained, even with negative acoustic effects of the skull in play. Experimental results show this methodology is able to produce both 2D and 3D images of the owing region, and eliminates those regions of static acoustic sources as predicted. Images produced of the owing region are found to agree with the physical size of the vessel analogues, and also found to provide a qualitative measure on the amount of flow through the vessels.

Citation Download Citation

Jeff Sadler, Zaki Ahmed, Kiyanoosh Shapoori , Adrian Wydra, Eugene Malyarenko , Elena Maeva, and Roman Gr. Maev "Development of a method to image blood flow beneath the skull or tissue using ultrasonic speckle reflections", Proc. SPIE 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, 86720G (29 March 2013); https://doi.org/10.1117/12.2002104

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