The DNA assembler for next generation sequencers

Jan Twardowski; Robert Nowak

doi:10.1117/12.2032637

25 October 2013 The DNA assembler for next generation sequencers

Jan Twardowski, Robert Nowak

Proceedings Volume 8903, Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2013; 890317 (2013) https://doi.org/10.1117/12.2032637
Event: Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2013, 2013, Wilga, Poland

Abstract

The aim of this paper is new application for de novo assembly DNA reads produced by next generation sequencers. The algorithm based on de Bruin graph is proposed, it uses both DNA strands: coding and complementary. The read errors are corrected. The repetitive sequences longer than read are correctly reconstructed in some cases. The application in client-server architecture was developed and tested on pseudo-random sequences and reads generated from genomes of model organisms.

Citation Download Citation

Jan Twardowski and Robert Nowak "The DNA assembler for next generation sequencers", Proc. SPIE 8903, Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2013, 890317 (25 October 2013); https://doi.org/10.1117/12.2032637

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