Photoacoustic microscopy of a three-dimensional arbitrary trajectory

Chenghung Yeh; Brian Soetikno; Song Hu; Konstantin I. Maslov; Lihong V. Wang

doi:10.1117/12.2037350

3 March 2014 Photoacoustic microscopy of a three-dimensional arbitrary trajectory

Chenghung Yeh, Brian Soetikno, Song Hu, Konstantin I. Maslov, Lihong V. Wang

Proceedings Volume 8943, Photons Plus Ultrasound: Imaging and Sensing 2014; 894351 (2014) https://doi.org/10.1117/12.2037350
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

We have developed three-dimensional arbitrary trajectory (3-DAT) scanning, which can rapidly image vessels of interest over a large field of view (FOV) and maintain a high signal-to-noise ratio (SNR) along the depth direction. The concept of 3-DAT scanning was demonstrated by imaging a human hair within a FOV of 3.5 × 2.0 mm². Further, we showed that hemoglobin oxygen saturation (sO₂) and blood flow can be measured simultaneously. The frame rate was 67 times faster than a traditional two-dimensional raster scan. We also observed sO₂ dynamics in response to a switch between systemic hyperoxia and hypoxia.

Citation Download Citation

Chenghung Yeh, Brian Soetikno, Song Hu, Konstantin I. Maslov, and Lihong V. Wang "Photoacoustic microscopy of a three-dimensional arbitrary trajectory", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894351 (3 March 2014); https://doi.org/10.1117/12.2037350

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