Binge consumption of ethanol during pregnancy leads to significant developmental delay of mouse embryonic brain

Narendran Sudheendran; Shameena Bake; Rajesh C. Miranda; Kirill V. Larin

doi:10.1117/12.2045528

4 March 2014 Binge consumption of ethanol during pregnancy leads to significant developmental delay of mouse embryonic brain

Narendran Sudheendran, Shameena Bake, Rajesh C. Miranda, Kirill V. Larin

Author Affiliations +

Proceedings Volume 8953, Optical Methods in Developmental Biology II; 89530D (2014) https://doi.org/10.1117/12.2045528
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Consumption of alcohol during pregnancy can be severely detrimental to the development of the brain in fetuses. This study explores the usage of optical coherence tomography (OCT) to the study the effects of maternal consumption of ethanol on brain development in mouse fetuses. On gestational day 14.5, fetuses were collected and fixed in 4% paraformaldehyde. A swept-source OCT (SSOCT) system was used to acquire 3D images of the brain of ethanol-exposed and control fetuses. The volume of right and left brain ventricles were measured and used to compare between ethanol-exposed and control fetuses. A total of 5 fetuses were used for each of the two groups. The average volumes of the right and left ventricles were measured to be 0.35 and 0.15 mm³ for ethanol-exposed and control fetuses, respectively. The results demonstrated that there is an alcohol-induced developmental delay in mouse fetal brains.

Citation Download Citation

Narendran Sudheendran, Shameena Bake, Rajesh C. Miranda, and Kirill V. Larin "Binge consumption of ethanol during pregnancy leads to significant developmental delay of mouse embryonic brain", Proc. SPIE 8953, Optical Methods in Developmental Biology II, 89530D (4 March 2014); https://doi.org/10.1117/12.2045528

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
5 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Brain

Fetus

Optical coherence tomography

Bioalcohols

Ultrasonography

3D image processing

HVAC controls

Show All Keywords

Keywords/Phrases

Search In:

Publication Years