Combining the correlation-stability approach to OCT elastography with the speckle-variance evaluation for quantifying the stiffness differences

Lev A. Matveev; Vladimir Yu. Zaitsev; Alexandr L. Matveyev; Grigory V. Gelikonov; Valentin M. Gelikonov

doi:10.1117/12.2052144

8 May 2014 Combining the correlation-stability approach to OCT elastography with the speckle-variance evaluation for quantifying the stiffness differences

Lev A. Matveev, Vladimir Yu. Zaitsev, Alexandr L. Matveyev, Grigory V. Gelikonov, Valentin M. Gelikonov

Author Affiliations +

Proceedings Volume 9129, Biophotonics: Photonic Solutions for Better Health Care IV; 91290I (2014) https://doi.org/10.1117/12.2052144
Event: SPIE Photonics Europe, 2014, Brussels, Belgium

Abstract

We discuss an advanced variant of the correlation-stability (CS) approach to OCT elastography that is capable of quantifying the stiffness differences. The modified variant is based on natural combination of CS approach with the speckle-variance (SV) approach. It allows one to determine the strain dependence of the normalized speckle intensity variance function for two compared subsets taken from the OCT images corresponding to the initial and deformed states of the tissue. In previous studies we considered the basic dependence of the normalized speckle intensity variance function on the tissue strain under the assumption that the influence of translational displacements can be excluded, so that the residual speckle-intensity variations should be produced only by speckle blinking determined by local strains. In the present report we discuss the corresponding algorithms allowing one to exclude the above-mentioned influence of translational displacements. We demonstrate numerically the efficiency of such processing that allows for quantification of stiffness differences in the elastographic mapping based on the CS approach.

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Lev A. Matveev, Vladimir Yu. Zaitsev, Alexandr L. Matveyev, Grigory V. Gelikonov, and Valentin M. Gelikonov "Combining the correlation-stability approach to OCT elastography with the speckle-variance evaluation for quantifying the stiffness differences", Proc. SPIE 9129, Biophotonics: Photonic Solutions for Better Health Care IV, 91290I (8 May 2014); https://doi.org/10.1117/12.2052144

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