Photoacoustic imaging of an inflammatory lesion model in the neonatal rat brain

Edgar Guevara; Romain Berti; Irène Londono; Ningshi Xie; Pierre Bellec; Frédéric Lesage; G. A. Lodygensky M.D.

doi:10.1117/12.2073720

25 September 2014 Photoacoustic imaging of an inflammatory lesion model in the neonatal rat brain

Edgar Guevara, Romain Berti, Irène Londono, Ningshi Xie, Pierre Bellec, Frédéric Lesage, G. A. Lodygensky M.D.

Proceedings Volume 9288, Photonics North 2014; 92880Q (2014) https://doi.org/10.1117/12.2073720
Event: Photonics North 2014, 2014, Montréal, Canada

Abstract

Periventricular leukomalacia (PVL) is a condition that may cause significant neurodevelopmental handicap in premature newborns. It is characterized by white matter injury, associated with inflammation. This work aimed to assess the impact of inflammation on cerebral oxygen saturation (sO₂) using depth-sensitive photoacoustic tomography (PAT). The aspects of PVL were reproduced in a rodent model by injection of lipopolysaccharide (LPS) into the corpus callosum. The results of this exploratory work reveal lower sO₂ values in LPS group, as compared to sham controls; showing decreased values in the corpus callosum and in the left cortex, ipsilateral to the injection site. Interhemispherical connectivity was not affected by LPS injection, as shown by functional connectivity analysis. This study supports the use of PAT as a non-invasive tool to assess oxygenation values in vivo in the newborn brain.

Citation Download Citation

Edgar Guevara, Romain Berti, Irène Londono, Ningshi Xie, Pierre Bellec, Frédéric Lesage, and G. A. Lodygensky M.D. "Photoacoustic imaging of an inflammatory lesion model in the neonatal rat brain", Proc. SPIE 9288, Photonics North 2014, 92880Q (25 September 2014); https://doi.org/10.1117/12.2073720

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KEYWORDS

Brain

Acquisition tracking and pointing

Inflammation

Neuroimaging

Photoacoustic imaging

Oxygen

Photoacoustic tomography

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