First multiphoton tomography of brain in man

Karsten König; Sven R. Kantelhardt M.D.; Darius Kalasauskas; Ella Kim; Alf Giese M.D.

doi:10.1117/12.2217730

9 March 2016 First multiphoton tomography of brain in man

Karsten König, Sven R. Kantelhardt M.D., Darius Kalasauskas, Ella Kim, Alf Giese M.D.

Proceedings Volume 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation; 96900A (2016) https://doi.org/10.1117/12.2217730
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We report on the first two-photon in vivo brain tissue imaging study in man. High resolution in vivo histology by multiphoton tomography (MPT) including two-photon FLIM was performed in the operation theatre during neurosurgery to evaluate the feasibility to detect label-free tumor borders with subcellular resolution. This feasibility study demonstrates, that MPT has the potential to identify tumor borders on a cellular level in nearly real-time.

Citation Download Citation

Karsten König, Sven R. Kantelhardt M.D., Darius Kalasauskas, Ella Kim, and Alf Giese M.D. "First multiphoton tomography of brain in man", Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 96900A (9 March 2016); https://doi.org/10.1117/12.2217730

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