Oxidative Processes In Photosensitization

Christopher S. Foote

doi:10.1117/12.960190

17 March 1989 Oxidative Processes In Photosensitization

Christopher S. Foote

Proceedings Volume 0997, Advances in Photochemotherapy; (1989) https://doi.org/10.1117/12.960190
Event: O-E/Fiber LASE '88, 1988, Boston, MA, United States

Abstract

Photosensitized oxidation is the key chemical process which causes cell toxicity in photodynamic therapy. The process is initiated by absorption of light by a sensitizer (Sens) to convert the sensitizer to an electronically excited state (Sens*). There are two principal reaction mechanisms, referred to as Type I or II, depending on whether the initial interaction of Sens* is with substrate or solvent, or with oxygen, respectively. The route actually adopted depends on oxygen and substrate concentration, and on substrate and sensitizer reactivity. Sensitizers may be dyes, pigments such as porphyrins, aromatic hydrocarbons, ketones or quinones, or a variety of other light-absorbing materials. Most types of photodynamic action involve absorption of visible light, although near-UV or infrared light can also be used in some cases.

Citation Download Citation

Christopher S. Foote "Oxidative Processes In Photosensitization", Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); https://doi.org/10.1117/12.960190

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available