Recovery of optical properties for antimicrobial photodynamic therapy treatment planning using a compact optical probe

Karina G. Bridger; Jacob R. Roccabruna; Timothy M. Baran

doi:10.1117/12.2608900

7 March 2022 Recovery of optical properties for antimicrobial photodynamic therapy treatment planning using a compact optical probe

Karina G. Bridger, Jacob R. Roccabruna, Timothy M. Baran

Author Affiliations +

Proceedings Volume PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX; (2022) https://doi.org/10.1117/12.2608900
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

In order to safely and effectively treat patients with methylene blue photodynamic therapy (MB-PDT) for sterilization of deep tissue abscesses, abscess optical properties must be determined. We demonstrate the ability of our compact optical probe along with a Monte Carlo-based lookup table to retrieve optical properties in tissue simulating phantoms containing Intralipid as a scatterer, and Methylene Blue (MB) and/or Mn(III) meso-Tetra (4-sulfonatophenyl) porphine (MnTPPS) as absorbers. Our results demonstrate the system’s ability to accurately recover optical properties in the presence of multiple absorbers. Future applications for this system will allow for patient specific treatment throughout ongoing clinical trials.

Conference Presentation

Citation Download Citation

Karina G. Bridger, Jacob R. Roccabruna, and Timothy M. Baran "Recovery of optical properties for antimicrobial photodynamic therapy treatment planning using a compact optical probe", Proc. SPIE PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, (7 March 2022); https://doi.org/10.1117/12.2608900

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