Frequency-domain near-infrared spectroscopy (fdNIRS) has been shown to be a promising tool for the diagnosis and monitoring of breast cancer treatment in point-of-care settings. However, current fdNIRS embodiments suffer from poor scalability and high complexity that has slowed their clinical translation. For the first time, we present a handheld, fully-wireless, multi-detector, multi-wavelength, fdNIRS system capable of real-time quantitative noninvasive measurements of optical properties and tissue chromophore concentrations at >10 kHz. High spatial resolution 2D topography images are displayed in real-time on a mobile platform with motion tracking. We characterize the system against prior generations, as well as in-vivo performance in human subjects.
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