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7 March 2022 Cellular resolution optical coherence tomography with the extended depth-of-focus by the diffractive optical element
Jingjing Zhao, yonatan Winetraub, Lin Du, Aidan Van Vleck, Adam de la Zerda
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Proceedings Volume PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; PC119480X (2022) https://doi.org/10.1117/12.2613303
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Focal size and depth-of-focus (DOF) are dependent by the numerical aperture (N.A.) of the lens. Consequently, a high-resolution image inherently results in a short DOF. In order to extend the DOF of a high N.A. lens, a novel diffractive optical element is developed to generate needle-shaped beams. The DOF can be enhanced from 12μm (two Rayleigh lengths) to 120μm with a constant diameter of 1.5μm (the same as the focal size). When applied to a virtual biopsy of human skin, the needle-shaped beam can reveal the individual cells in the epidermal layer.
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Jingjing Zhao, yonatan Winetraub, Lin Du, Aidan Van Vleck, and Adam de la Zerda "Cellular resolution optical coherence tomography with the extended depth-of-focus by the diffractive optical element", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC119480X (7 March 2022); https://doi.org/10.1117/12.2613303
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KEYWORDS
Diffractive optical elements
Optical coherence tomography
Optical resolution
Objectives
Skin
Gaussian beams
Laser scattering
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