Dual PpIX and moxifloxacin fluorescence confocal imaging for brain tumor delineation​

Seonghan Kim; Seunghun Lee; Kihean Kim; Eui Hyun Kim; Kyung Hwa Lee; Chulmin Joo

doi:10.1117/12.2610940

9 March 2022 Dual PpIX and moxifloxacin fluorescence confocal imaging for brain tumor delineation

Seonghan Kim, Seunghun Lee, Kihean Kim, Eui Hyun Kim, Kyung Hwa Lee, Chulmin Joo

Proceedings Volume PC11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX; PC1194907 (2022) https://doi.org/10.1117/12.2610940
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

5-ALA-based fluorescence-guided surgery (FGS) is a state-of-the-art treatment for brain tumors, but may miss areas due to its low sensitivity. To improve the sensitivity we developed dual PpIX and Moxifloxacin Fluorescence Confocal Imaging method that allows simultaneous imaging of 5-ALA and moxifloxacin by excitation with a single light source. This method verified by comparing confocal images in glioblastoma specimen. The distribution of cells expressing 5-ALA and moxifloxacin fluorescence signals showed the same correlation. In large-area tumor sample images, PplX showed differences in signal intensity, but moxifloxacin was constant. These results show the potential to improve sensitivity than with 5-ALA alone.

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Citation Download Citation

Seonghan Kim, Seunghun Lee, Kihean Kim, Eui Hyun Kim, Kyung Hwa Lee, and Chulmin Joo "Dual PpIX and moxifloxacin fluorescence confocal imaging for brain tumor delineation", Proc. SPIE PC11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX, PC1194907 (9 March 2022); https://doi.org/10.1117/12.2610940

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KEYWORDS

Luminescence

Tumors

Confocal microscopy

Brain

Neuroimaging

Surgery

Microscopes

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