Numerical studies for exploring the effect of cold surface thermal conditions on two-photon brain imaging

Aditya Roy; Adela Ben-Yakar

doi:10.1117/12.2609232

7 February 2023 Numerical studies for exploring the effect of cold surface thermal conditions on two-photon brain imaging

Aditya Roy, Adela Ben-Yakar

Author Affiliations +

Proceedings Volume PC11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology; PC1195805 (2023) https://doi.org/10.1117/12.2609232
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

In an effort to better understand the functioning of the brain, a new two-photon imaging modality being developed by our group aims to achieve unprecedented imaging speeds at up to 100 kHz. The high powers required for facilitating the same pose the risk of brain heating beyond established thermal limits. This work explores various theoretical boundary conditions for evaluating the impact on resulting spatiotemporal thermal distribution for an input parameter space at 1035nm excitation wavelength using an MC-FDM coupled numerical model with an aim of further paving way towards devising cooling strategies for deep brain imaging.

Conference Presentation

Citation Download Citation

Aditya Roy and Adela Ben-Yakar "Numerical studies for exploring the effect of cold surface thermal conditions on two-photon brain imaging", Proc. SPIE PC11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology, PC1195805 (7 February 2023); https://doi.org/10.1117/12.2609232

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