Combining OCE and Brillouin microscopy to evaluate in vivo lens biomechanics in 3D

Justin Schumacher; Alexander W. Schill; Manmohan Singh; Fabrice Manns; Kirill V. Larin; Giuliano Scarcelli

doi:10.1117/12.2649355

17 March 2023 Combining OCE and Brillouin microscopy to evaluate in vivo lens biomechanics in 3D

Justin Schumacher, Alexander W. Schill, Manmohan Singh, Fabrice Manns, Kirill V. Larin, Giuliano Scarcelli

Proceedings Volume PC12360, Ophthalmic Technologies XXXIII; PC123600N (2023) https://doi.org/10.1117/12.2649355
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Presbyopia is a loss of the dynamic accommodation response of our vision and affects everybody as they age. Despite many static treatment options, we still do not address the biomechanical cause of lens stiffness. Novel therapies are limited by no ability to monitor in vivo biomechanics. To address this unmet need, we developed a combination OCE/Brillouin system capable of measuring co-located Brillouin spectra and elastography information to derive depth-dependent elastic moduli. The system specifications were quantified for evaluating a human lens and testing performed in vivo. This technique has the potential for patient-specific predictive models of presbyopia.

Conference Presentation

Citation Download Citation

Justin Schumacher, Alexander W. Schill, Manmohan Singh, Fabrice Manns, Kirill V. Larin, and Giuliano Scarcelli "Combining OCE and Brillouin microscopy to evaluate in vivo lens biomechanics in 3D", Proc. SPIE PC12360, Ophthalmic Technologies XXXIII, PC123600N (17 March 2023); https://doi.org/10.1117/12.2649355

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available