Raman spectrosopy for monitoring of engineered cartilage growth

Dev Mehrotra; Juncheng Zhang; Tianbai Wang; Diya Desai; Mark Grinstaff; Brian Snyder; Mads Bergholt; Michael Albro

doi:10.1117/12.2650163

6 March 2023 Raman spectrosopy for monitoring of engineered cartilage growth

Dev Mehrotra, Juncheng Zhang, Tianbai Wang, Diya Desai, Mark Grinstaff, Brian Snyder, Mads Bergholt, Michael Albro

Proceedings Volume PC12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI; PC123680K (2023) https://doi.org/10.1117/12.2650163
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

This work investigates the capability of a novel Raman arthroscopic needle probe to assess cartilage-tissue-specific biomarkers that are predictive of articular cartilage health during the progression of osteoarthritis. Using ex vivo models of cartilage over a range of degenerative states, we demonstrate that Raman probe-derived biomarkers can predict the composition and material properties of cartilage tissue specimens. This work supports the future use of Raman arthroscopy as an intraarticular clinical platform for ‘molecular assessment’ cartilage to achieve diagnostics of osteoarthritis early in the disease process and assess the efficacy of emerging clinical therapies in restoring cartilage health.

Conference Presentation

Citation Download Citation

Dev Mehrotra, Juncheng Zhang, Tianbai Wang, Diya Desai, Mark Grinstaff, Brian Snyder, Mads Bergholt, and Michael Albro "Raman spectrosopy for monitoring of engineered cartilage growth", Proc. SPIE PC12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, PC123680K (6 March 2023); https://doi.org/10.1117/12.2650163

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