Multiplatform and synergetic photothermal heating using plasmonic gold nanostars

Ren A. Odion; Yang Liu; Stephen J. Norton; Tuan Vo-Dinh

doi:10.1117/12.2650598

31 March 2023 Multiplatform and synergetic photothermal heating using plasmonic gold nanostars

Ren A. Odion, Yang Liu, Stephen J. Norton, Tuan Vo-Dinh

Proceedings Volume PC12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI; PC123680Q (2023) https://doi.org/10.1117/12.2650598
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Gold nanostars (GNS) have increasingly seen usage in photothermal treatment of diseases such as cancer. Owing to their flexible synthesis, GNS can be easily tuned to absorption wavelengths that bypass the absorption of non-target tissue. The particles can also be easily coupled with other sensing modalities such as molecular imaging using surface-enhanced Raman spectroscopy (SERS) and Immunotherapy in a synergistic manner. We have developed a combination treatment for cancer therapy called Synergistic Immuno Photo Nanotherapy (SYMPHONY) effectively uses photothermal heating as an adjunct treatment with immune check-point inhibitors. Here we develop several methods to simulate and analyze the optical and thermal effects of GNS absorption. In particular, the optimal conditions of GNS heating are investigated for understanding specific targeted therapy with limitations surrounding tissue absorption.

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Citation Download Citation

Ren A. Odion, Yang Liu, Stephen J. Norton, and Tuan Vo-Dinh "Multiplatform and synergetic photothermal heating using plasmonic gold nanostars", Proc. SPIE PC12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, PC123680Q (31 March 2023); https://doi.org/10.1117/12.2650598

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KEYWORDS

Gold

Absorption

Plasmonics

Cancer

Oncology

Surface enhanced Raman spectroscopy

Tissues

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