A continuous line scanning method for fast temperature modulated fluorescence tomography

Farouk Nouizi; Hakan Erkol; Deniz Nikkhah; Tiffany C. Kwong; Gultekin Gulsen

doi:10.1117/12.2651104

7 March 2023 A continuous line scanning method for fast temperature modulated fluorescence tomography

Farouk Nouizi, Hakan Erkol, Deniz Nikkhah, Tiffany C. Kwong, Gultekin Gulsen

Proceedings Volume PC12376, Optical Tomography and Spectroscopy of Tissue XV; PC123760Q (2023) https://doi.org/10.1117/12.2651104
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We previously introduced a novel method called temperature modulated fluorescence tomography (TMFT), which utilizes temperature sensitive ICG loaded pluronic nanocapsules termed ThermoDots and high intensity focused ultrasound (HIFU). TMFT leverages the superior sensitivity of the fluorescence imaging and the high spatial-resolution of focused ultrasound. Previously, we have presented a prototype system using a CCD camera. However, the scan time was too long for in vivo imaging since HIFU was scanned in a step-and-shoot mode. Here, we present the new continuous line scanning scheme, which drastically reduces the imaging time and paves the wave for in vivo preclinical imaging.

Conference Presentation

Citation Download Citation

Farouk Nouizi, Hakan Erkol, Deniz Nikkhah, Tiffany C. Kwong, and Gultekin Gulsen "A continuous line scanning method for fast temperature modulated fluorescence tomography", Proc. SPIE PC12376, Optical Tomography and Spectroscopy of Tissue XV, PC123760Q (7 March 2023); https://doi.org/10.1117/12.2651104

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