OCTA-guided high-speed photo-mediated ultrasound therapy

Yuchen Song; Shuang Wei; Yan Li; Zhongping Chen

doi:10.1117/12.2651325

7 March 2023 OCTA-guided high-speed photo-mediated ultrasound therapy

Yuchen Song, Shuang Wei, Yan Li, Zhongping Chen

Proceedings Volume PC12377, Optical Interactions with Tissue and Cells XXXIV; PC1237703 (2023) https://doi.org/10.1117/12.2651325
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Photo-mediated Ultrasound Therapy (PUT) is a novel anti-vascular and agree-free technique, which can selectively remove blood vessels by promoting cavitation activity with a significantly lower amount of energy of ultrasound burst and nanosecond laser simultaneity when compared to energy level required by individual laser and ultrasound treatment therapies. We report the development of a high-speed PUT system with 50 kHz pulsed laser, decreasing the treatment time by a factor of 20. In addition, we combined it with optical coherence tomography angiography (OCTA) for real-time monitoring in vivo rabbit experiments. Based on quantitative prescreening and real-time monitoring of treatment response, this combination enables implementation of individualized treatment strategies.

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Citation Download Citation

Yuchen Song, Shuang Wei, Yan Li, and Zhongping Chen "OCTA-guided high-speed photo-mediated ultrasound therapy", Proc. SPIE PC12377, Optical Interactions with Tissue and Cells XXXIV, PC1237703 (7 March 2023); https://doi.org/10.1117/12.2651325

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KEYWORDS

Ultrasonography

Laser therapeutics

Blood vessels

Ear

In vivo imaging

Capillaries

Cavitation

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