CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC12397 > Article
Presentation
17 March 2023 High throughput optical modulation biosensing for highly sensitive and mass scale rapid detection of Covid-19 (Conference Presentation)
Shmuel Burg, Shira Roth, Meir Cohen, Shira Avivi-Mintz, Michael Margulis, Hanan Rohana, Avi Peretz, Amos Danielli
Author Affiliations +
Proceedings Volume PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV; PC1239706 (2023) https://doi.org/10.1117/12.2649758
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Rapid, highly sensitive, and high-throughput detection of biomarkers at low concentrations is invaluable for early diagnosis of various diseases. In many sensitive immunoassays the protocol is time consuming and requires a complicated and expensive detection system. Here, we demonstrate a high-throughput optical modulation biosensing (ht-OMB) system, which enables reading a 96-well plate within 10 minutes. Using the system, to detect human Interleukin-8, we demonstrated a limit of detection of 0.14 ng/L and a 4-log dynamic range. Testing 94 RNA extracts from 36 confirmed RT-qPCR SARS-CoV-2-positive patients (C_t≤40) and 58 confirmed RT-qPCR SARS-CoV-2-negative individuals resulted in 100% sensitivity and 100% specificity.
Conference Presentation
© (2023) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Shmuel Burg, Shira Roth, Meir Cohen, Shira Avivi-Mintz, Michael Margulis, Hanan Rohana, Avi Peretz, and Amos Danielli "High throughput optical modulation biosensing for highly sensitive and mass scale rapid detection of Covid-19 (Conference Presentation)", Proc. SPIE PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV, PC1239706 (17 March 2023); https://doi.org/10.1117/12.2649758
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Biosensing
Modulation
Magnetism
Molecules
Point-of-care devices
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top