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In this study, we demonstrate the potential manufacturing method and application of 2D WSe2-based field-effect transistors (2D-FETs) as a promising biosensor for the selective and rapid detection of a pathogen such as SARS-CoV-2 in vitro. The sensors are manufactured by first synthesizing 2D material on Si/SiO2 substrates, followed by photolithography processes to form the FET devices. Then, the surface of 2D material WSe2 has been functionalized with a specific antibody to selectively detect the SARS-CoV-2 spike protein. The TMDC-based 2D-FETs can potentially serve as sensitive and selective biosensors for the rapid detection of infectious diseases.
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Parvin Fathi-Hafshejani, Nurul Azam, Suman Jaiswal, Lu Wang, Marcelo Kuroda, Michael C. Hamilton, Sahar Hasim, Masoud Mahjouri-Samani, "2D materials-based biosensor for detecting COVID-19 virus (Conference Presentation)," Proc. SPIE PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV, PC1239707 (17 March 2023); https://doi.org/10.1117/12.2650741