NIR I cyanine dyes complexed with engineered albumin fragments for NIR II fluorescence imaging (Conference Presentation)

Xiaoyuan Chen

doi:10.1117/12.2653799

17 March 2023 NIR I cyanine dyes complexed with engineered albumin fragments for NIR II fluorescence imaging (Conference Presentation)

Xiaoyuan Chen

Author Affiliations +

Proceedings Volume PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV; PC1239801 (2023) https://doi.org/10.1117/12.2653799
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

This talk will highlight a genetic engineering technique to obtain a series of albumin fragments and recombinant proteins containing one or multiple domains that form covalent bonds with chloro-containing cyanine dyes. These albumin variants protect the inserted dyes and remarkably enhance their brightness. The albumin variants can also be genetically edited to develop size-tunable complexes with precisely tailored pharmacokinetics. The proteins can also be conjugated to biofunctional molecules without impacting the complexed dyes. This combination of albumin mutants and clinically-used cyanine dyes can help widen the clinical application prospects of NIR I fluorophores to be visualized in the NIR II window.

Conference Presentation

Citation Download Citation

Xiaoyuan Chen "NIR I cyanine dyes complexed with engineered albumin fragments for NIR II fluorescence imaging (Conference Presentation)", Proc. SPIE PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV, PC1239801 (17 March 2023); https://doi.org/10.1117/12.2653799

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