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17 March 2023 Plasmonic solid-state nanopores: toward single-molecule protein and DNA identification
Francesco De Angelis
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Proceedings Volume PC12425, Smart Photonic and Optoelectronic Integrated Circuits 2023; PC124250M (2023) https://doi.org/10.1117/12.2653096
Event: SPIE OPTO, 2023, San Francisco, California, United States
Abstract
The success of nanopore sequencers for DNA has inspired extensive research on proteins. However, when moving to proteins some major challenges remain, among them: 1) DNA bases are just 4 against the amino acids which are 20; (2) spatial and temporal resolution (sensitivity) to discriminate single amino acids within the same molecule. In this context, label-free optical analysis based on plasmonic enhancement shows great promises. In fact, plasmonic nanopores can confine and amplifying the local electromagnetic field into the pore (challenge #2). The confinement improves the spatial resolution while the amplification increases the sensitivity. Notably, Raman spectroscopy provides unique molecular fingerprints to discriminate amino acids (challenge #1). We show our latest results on extreme plasmonic nanopores combined with Raman Spectroscopy for amino acids identification and sequencing at single molecule level in label-free. We acknowledge support from Horizon 2020 (ProID GA 964363).
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Francesco De Angelis "Plasmonic solid-state nanopores: toward single-molecule protein and DNA identification", Proc. SPIE PC12425, Smart Photonic and Optoelectronic Integrated Circuits 2023, PC124250M (17 March 2023); https://doi.org/10.1117/12.2653096
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KEYWORDS
Proteins
Plasmonics
Solid state physics
DNA profiling
Molecules
Optical analysis
Surface enhanced Raman spectroscopy
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