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Flow cytometry is one of the most widespread optical methods used in the diagnosis of health disorders and disease monitoring. The ultimate goal is achieving a single biomarker sensitivity. Here we experimentally characterize the nonclassical light from the flow cytometer and observe g(2)(0) = 0.4(2). Thus, we demonstrate a single emitter sensitivity and determine that the signal due to one biomarker is at least 6 times brighter than the background noise. This result potentially enables detecting rare single biomarker occurrences with high throughput.
Ivan A. Burenkov,Javier Sabines-Chesterking, andSergey V. Polyakov
"Quantum measurement enables single-biomarker detection in flow cytometers", Proc. SPIE PC12447, Quantum Sensing, Imaging, and Precision Metrology, PC1244737 (9 March 2023); https://doi.org/10.1117/12.2649396
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Ivan A. Burenkov, Javier Sabines-Chesterking, Sergey V. Polyakov, "Quantum measurement enables single-biomarker detection in flow cytometers," Proc. SPIE PC12447, Quantum Sensing, Imaging, and Precision Metrology, PC1244737 (9 March 2023); https://doi.org/10.1117/12.2649396