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9 March 2023 Quantum measurement enables single-biomarker detection in flow cytometers
Ivan A. Burenkov, Javier Sabines-Chesterking, Sergey V. Polyakov
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Proceedings Volume PC12447, Quantum Sensing, Imaging, and Precision Metrology; PC1244737 (2023) https://doi.org/10.1117/12.2649396
Event: SPIE Quantum West, 2023, San Francisco, California, United States
Abstract
Flow cytometry is one of the most widespread optical methods used in the diagnosis of health disorders and disease monitoring. The ultimate goal is achieving a single biomarker sensitivity. Here we experimentally characterize the nonclassical light from the flow cytometer and observe g(2)(0) = 0.4(2). Thus, we demonstrate a single emitter sensitivity and determine that the signal due to one biomarker is at least 6 times brighter than the background noise. This result potentially enables detecting rare single biomarker occurrences with high throughput.
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Ivan A. Burenkov, Javier Sabines-Chesterking, and Sergey V. Polyakov "Quantum measurement enables single-biomarker detection in flow cytometers", Proc. SPIE PC12447, Quantum Sensing, Imaging, and Precision Metrology, PC1244737 (9 March 2023); https://doi.org/10.1117/12.2649396
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KEYWORDS
Quantum dots
Biological research
Biomedical optics
Calibration
Particles
Photodetectors
Picosecond phenomena
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