Near-infrared II photobiomodulation to treat cardiovascular diseases via restoring endothelial nitric oxide bioavailability

Shinya Yokomizo; Denis E. Bragin; Dmitry Gerashchenko; Dmitriy N. Atochin; Satoshi Kashiwagi

doi:10.1117/12.3003398

13 March 2024 Near-infrared II photobiomodulation to treat cardiovascular diseases via restoring endothelial nitric oxide bioavailability

Shinya Yokomizo, Denis E. Bragin, Dmitry Gerashchenko, Dmitriy N. Atochin, Satoshi Kashiwagi

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Proceedings Volume PC12826, Mechanisms of Photobiomodulation Therapy XVIII; PC1282604 (2024) https://doi.org/10.1117/12.3003398
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Photobiomodulation (PBM) with low-power near-infrared (NIR) light has shown diverse beneficial effects. Recent studies report that PBM also increases bioavailable nitric oxide (NO), which is a critical gaseous mediator for various physiological processes and could be used to treat cardiovascular and cerebrovascular diseases with suppressed endothelial NO production. We explored using NIR-II light (1000-1700 nm) for PBM. NIR-II laser treatment efficiently enhanced NO generation in endothelial cells. Since impaired NO production is also associated with neurological diseases, this novel therapy could be further explored to treat diseases such as traumatic brain injury, sleep disorders, and Alzheimer's disease.

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Shinya Yokomizo, Denis E. Bragin, Dmitry Gerashchenko, Dmitriy N. Atochin, and Satoshi Kashiwagi "Near-infrared II photobiomodulation to treat cardiovascular diseases via restoring endothelial nitric oxide bioavailability", Proc. SPIE PC12826, Mechanisms of Photobiomodulation Therapy XVIII, PC1282604 (13 March 2024); https://doi.org/10.1117/12.3003398

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KEYWORDS

NOx

Cardiovascular disorders

Laser therapeutics

Mitochondria

Cerebrovascular diseases

Near infrared

Light scattering

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