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13 March 2024 Dual comb diffuse correlation spectroscopy
Binbin Zhang, Christopher Phillips, Esteban Venialgo Araujo, Sophinese Iskander-Rizk, Justinas Pupeikis, Benjamin Willenberg, Ursula Keller, Nandini Bhattacharya
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Proceedings Volume PC12828, Neural Imaging and Sensing 2024; PC128280K (2024) https://doi.org/10.1117/12.3011659
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Diffuse Correlation Spectroscopy (DCS) is an emerging technique capable of measuring cerebral dynamics. To obtain a reliable blood flow index (BFi), DCS often collaborates with near-infrared spectroscopy (NIRS) to provide measurements of static optical properties of tissue. The integration of these two techniques into a single modality has been a subject of ongoing research interest. While dual-comb spectroscopy offers a promising solution, it is often impeded by high costs and complex instrumentation. In this study, we present an innovative approach that employs a single-cavity free-running dual-comb source and balanced detectors to construct two Mach-Zehnder interferometers. Our results indicate that, even in the absence of feedback control loops and single-photon detectors, both static and dynamic properties of bio-phantoms can be simultaneously measured. This approach holds the potential to offer a simplified, cost-effective solution for DCS, NIRS, and optical coherence tomography (OCT).
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Binbin Zhang, Christopher Phillips, Esteban Venialgo Araujo, Sophinese Iskander-Rizk, Justinas Pupeikis, Benjamin Willenberg, Ursula Keller, and Nandini Bhattacharya "Dual comb diffuse correlation spectroscopy", Proc. SPIE PC12828, Neural Imaging and Sensing 2024, PC128280K (13 March 2024); https://doi.org/10.1117/12.3011659
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KEYWORDS
Spectroscopy
Near infrared spectroscopy
Absorption
Computed tomography
Magnetic resonance imaging
Physical coherence
Picosecond phenomena
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