Interrogating visual deficits in dementia using high-density diffuse optical tomography (HD-DOT)

Emilia Butters; Sruthi Srinivasan; Deepshikha Acharya; John O'Brien; Li Su; Gemma M. Bale

doi:10.1117/12.3021131

13 March 2024 Interrogating visual deficits in dementia using high-density diffuse optical tomography (HD-DOT)

Emilia Butters, Sruthi Srinivasan, Deepshikha Acharya, John O'Brien, Li Su, Gemma M. Bale

Proceedings Volume PC12828, Neural Imaging and Sensing 2024; PC1282810 (2024) https://doi.org/10.1117/12.3021131
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Measures of vascular dysfunction may serve as valuable clinical markers for the early detection of dementia, and for monitoring its progression. Near-Infrared Spectroscopy (NIRS) can non-invasively measure brain oxygenation by quantifying concentration changes of oxygenated (HbO) and deoxygenated haemoglobin (HbR). NIRS shows much promise for clinical translation: it has few contraindications, it can be performed at the bedside, and it is low-cost. High-Density Diffuse Optical Tomography (HD-DOT) extends this method by combining high-density NIRS with anatomical information to produce volumetric or topographical maps of brain oxygenation. Here we present an observational cohort study for Alzheimer's disease, dementia with Lewy bodies or mild cognitive impairment (n=32), which for the first time evaluates the possibility of using HD-DOT to develop biomarkers for dementia. Our early findings show that visual stimulation elicits a reduction in the magnitude of concentration changes of both HbO and HbR in Alzheimer’s Disease compared to healthy controls.

Citation Download Citation

Emilia Butters, Sruthi Srinivasan, Deepshikha Acharya, John O'Brien, Li Su, and Gemma M. Bale "Interrogating visual deficits in dementia using high-density diffuse optical tomography (HD-DOT)", Proc. SPIE PC12828, Neural Imaging and Sensing 2024, PC1282810 (13 March 2024); https://doi.org/10.1117/12.3021131

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available