Age-related macular degeneration (AMD) is a leading cause of global irreversible vision loss, with wet AMD responsible for over 90% of AMD-related vision loss. The laser-induced CNV mouse model is commonly used to study wet AMD. For this study, a functional retinal imaging system was used to investigate the pathological characteristics of laser-induced CNV in mice, providing advanced resolution to visualize structural, vascular, and molecular-specific features of the lesions and outer retinal layers.
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