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This work develops a thorough and user-friendly methodology for fluence compensation of photoacoustic (PA) data from the commercial Visualsonics (VS) VevoLAZR-X System. PHANTOM (PHotoacoustic ANnotation TOolkit) has been created to help fluence compensate large PA datasets. PHANTOM provides an easy-to-use graphical user interface to assist users in segmenting US-coupled PA images into three-dimensional labeled tissue structures with assignable optical characteristics. We also modeled an MCX-compatible light source configuration that replicates the VS system's optical fiber illumination. PHANTOM exports all Monte Carlo configuration parameters which are compatible with Monte Carlo eXtreme (MCX) allowing fluence compensation of PA data.
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