Deep optical microscopy based on gas bubbles generated by combined ultrasound and optical energies

Jinwoo Kim; Haemin Kim; Jin Ho Chang

doi:10.1117/12.3002205

13 March 2024 Deep optical microscopy based on gas bubbles generated by combined ultrasound and optical energies

Jinwoo Kim, Haemin Kim, Jin Ho Chang

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128421J (2024) https://doi.org/10.1117/12.3002205
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Although several optical imaging modalities can acquire high-resolution images, the light penetration depth is limited because optical scattering occurs in a tissue, making it difficult to acquire deep-depth images. For this reason, we previously suggested and verified that ultrasound-induced optical clearing microscopy (US-OCM) can suppress optical scattering and improve the depth of light penetration. However, it is challenging to accurately predict the nucleation position of a bubble cloud due to randomly generated within the depth of focus. In this study, we proposed a combined acoustic and optical cavitation-induced gas bubbles method that can generate a bubble cloud at an accurately predicted location, and demonstrate image performance through various experiments.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Jinwoo Kim, Haemin Kim, and Jin Ho Chang "Deep optical microscopy based on gas bubbles generated by combined ultrasound and optical energies", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128421J (13 March 2024); https://doi.org/10.1117/12.3002205

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available