Monitoring peripheral perfusion during hemodynamic challenges in human subjects with a low-cost optical wearable device

Francescsa Bonetta-Misteli; Madison Carlgren; Kelly Liang; Xiyan Li; Miranda Bagar; Laura Brown; Leonid Shmuylovich; Christine M. O'Brien

doi:10.1117/12.3000565

13 March 2024 Monitoring peripheral perfusion during hemodynamic challenges in human subjects with a low-cost optical wearable device

Francescsa Bonetta-Misteli, Madison Carlgren, Kelly Liang, Xiyan Li, Miranda Bagar, Laura Brown, Leonid Shmuylovich, Christine M. O'Brien

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Proceedings Volume PC12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics; PC128500A (2024) https://doi.org/10.1117/12.3000565
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

A compact, low-cost (<$150), wearable device that continuously monitors peripheral perfusion via laser speckle flow index (LSFI) was used to measure changes in blood flow in human subjects during a set of physiological challenges. One group (A) of subjects underwent arm occlusion followed by exercise (n=3) and a second group (B) of subjects underwent arm occlusion, cold stimulation, and exercise (n=4). Cold stimulation alone did not cause significant changes from baseline LSFI. The rate of increase of the LSFI signal over the 5-minute exercise period was 3 times larger in group A compared to group B. Although cold stimulation alone did not appear to cause vasoconstriction in the wrist, it did impact the rate at which perfusion increases during exercise. The low-cost device consistently monitored changes in hemodynamics in all subjects, including both increases and decreases in blood flow caused by occlusion and sympathetic nervous system stimulation.

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Francescsa Bonetta-Misteli, Madison Carlgren, Kelly Liang, Xiyan Li, Miranda Bagar, Laura Brown, Leonid Shmuylovich, and Christine M. O'Brien "Monitoring peripheral perfusion during hemodynamic challenges in human subjects with a low-cost optical wearable device", Proc. SPIE PC12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics, PC128500A (13 March 2024); https://doi.org/10.1117/12.3000565

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KEYWORDS

Hemodynamics

Human subjects

Wearable devices

Optical sensing

Cameras

Instrument modeling

Laser development

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