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13 March 2024 From concept to commercialization: automated high throughput optical modulation biosensing for detection of low concentrations of biomarkers
Shmuel Burg, Meir Cohen, Michael Margulis, Reut Askenasy, Amos Danielli
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Proceedings Volume PC12861, Frontiers in Biological Detection: From Nanosensors to Systems XVI; PC1286109 (2024) https://doi.org/10.1117/12.3008274
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Rapid, highly sensitive, and high-throughput detection of biomarkers at low concentrations is invaluable for the early diagnosis of various diseases. In many sensitive immunoassays, the protocol is time-consuming and requires a complicated and expensive detection system. Previously, we presented a high-throughput optical modulation biosensing (ht-OMB) system, which enables reading a 96-well plate within 10 minutes. In ht-OMB, to aggregate and immobilize the magnetic beads to one spot, a single cylindrical permanent magnet with a sharp tip is positioned under a 96-well plate. To reduce washing and separation steps, the laser beam is manipulated relative to the fixed magnetic beads. Recently, MagBiosense Inc., which commercializes the ht-OMB technology, provided us with a fully automated OMBi detection system. Here, we show the use of the OMBi system for highly sensitive serological (clinical anti-Zika, anti-DENV, and anti-West Nile IgG) and molecular (SARS-CoV-2) assays. Using the OMBi, to detect 336 RNA extracts from 70 confirmed RT-qPCR SARS-CoV-2-positive patients (Ct≤40) and 236 confirmed RT-qPCR SARS-CoV-2-negative individuals, resulted in 100% specificity and 96% sensitivity.
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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Shmuel Burg, Meir Cohen, Michael Margulis, Reut Askenasy, and Amos Danielli "From concept to commercialization: automated high throughput optical modulation biosensing for detection of low concentrations of biomarkers", Proc. SPIE PC12861, Frontiers in Biological Detection: From Nanosensors to Systems XVI, PC1286109 (13 March 2024); https://doi.org/10.1117/12.3008274
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KEYWORDS
Biosensing
Modulation
Commercialization
Magnetism
Diseases and disorders
Calibration
Displays
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