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13 March 2024 Development of near-infrared fluorophores for improved nerve-sparing surgical procedures
Lei G. Wang, Connor Barth, Antonio Montaño, Anas Masillati, Dani Szafran, Summer Gibbs
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Proceedings Volume PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; PC1286205 (2024) https://doi.org/10.1117/12.3003618
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Fluorescence-guided surgery (FGS) has the potential to significantly enhance patient outcomes by enabling precise real-time visualization of vital nerve structures during surgical procedures. However, a clinically approved nerve-specific contrast agent does not exist. To address this need, we adopted a medicinal chemistry approach to design and develop novel near-infrared (NIR) nerve-binding small molecule fluorophore libraries. Our first-in-class NIR nerve-binding small molecule fluorophores represent a significant advancement in the field. By enabling precise nerve visualization in real-time during surgery, these contrast agents have the potential to revolutionize nerve-sparing procedures and ultimately improve patient outcomes.
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Lei G. Wang, Connor Barth, Antonio Montaño, Anas Masillati, Dani Szafran, and Summer Gibbs "Development of near-infrared fluorophores for improved nerve-sparing surgical procedures", Proc. SPIE PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, PC1286205 (13 March 2024); https://doi.org/10.1117/12.3003618
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KEYWORDS
Nerve
Fluorophores
Near infrared
Visualization
Contrast agents
Imaging systems
Injuries
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