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13 March 2024 ThermoDots: temperature modulated fluorescent contrast agents for high resolution fluorescence imaging
Farouk Nouizi, Tiffany Kwong, Uma Sampathkumaran, Gultekin Gulsen
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Proceedings Volume PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; PC128620F (2024) https://doi.org/10.1117/12.3005052
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
In vivo tumor imaging and delineating tumor margins serves a critical role in early detection and treatment of cancer. Together with our industrial collaborators, InnoSense LLC (Torrance, CA), we previously have developed ThermoDots™, temperature-responsive micelles that encapsulate an FDA approved near infrared (NIR) imaging agent, indocyanine green (ICG). ThermoDots enhances the signal and enable high resolution fluorescence imaging capability. In this work, they are conjugated with PSMA antibodies for prostate cancer imaging.
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Farouk Nouizi, Tiffany Kwong, Uma Sampathkumaran, and Gultekin Gulsen "ThermoDots: temperature modulated fluorescent contrast agents for high resolution fluorescence imaging", Proc. SPIE PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, PC128620F (13 March 2024); https://doi.org/10.1117/12.3005052
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KEYWORDS
Fluorescence imaging
Image resolution
In vivo imaging
Modulation
Contrast agents
Fluorescence
Near infrared
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